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KMID : 0615720090260010039
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Jouranl of Korean Acupuncture and Moxibustion society
2009 Volume.26 No. 1 p.39 ~ p.47
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The Effect of Acupuncture on Methamphetamine-induced Locomotor Activity and C-Fos Expression in Rat Brain
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Choi Seong-Hun
Park In-Sik
Lee Bong-Hyo
Yang Chae-Ha
Choi Nan-Hee
Kim Kwang-Joong
Song Ick-Soo
Jang Eun-Young
Ku Sae-Kwang
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Abstract
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Objectives : The mesolimbic dopamine system is believed to play a major role in the reinforcing effect and behavioral hyperactivity of abused drugs including methamphetamine. In the present study, the effect of acupuncture on methamphetamine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens of rats were examined.
Methods : Male Sprague-Dawley rats received acupuncture at bilateral Yanggu() point for 30seconds immediately before the subcutaneous injection of saline or methamphetamine(0.5mg/kg). The total amount of locomotor activity for 90min were measured just before brain samples were taken for immunohistochemistry.
Results : Results showed that acupuncture at the specific point , but not control point(Kunlun, ) significantly reduced locomotor activity and c-Fos expression in the striatum and nucleus accumbens induced by acute administration of methamphetamine.
Conclusions : These results suggest that acupuncture may be effective in suppressing the reinforcing effect of methamphetamine by regulating neuronal activity.
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KEYWORD
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acupuncture, methamphetamine, Locomotor activity, c-Fos
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